Search on: CYCLIC GMP 
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Descriptor English:   Cyclic GMP 
Descriptor Spanish:   GMP Cíclico 
Descriptor Portuguese:   GMP Cíclico 
Synonyms English:   Guanosine Cyclic 3',5'-Monophosphate  
Tree Number:   D03.438.759.646.454.160
D13.695.462.275
D13.695.667.454.160
D13.695.827.426.160
Definition English:   Guanosine cyclic 3',5'-(hydrogen phosphate). A guanine nucleotide containing one phosphate group which is esterified to the sugar moiety in both the 3'- and 5'-positions. It is a cellular regulatory agent and has been described as a second messenger. Its levels increase in response to a variety of hormones, including acetylcholine, insulin, and oxytocin and it has been found to activate specific protein kinases. (From Merck Index, 11th ed) 
Indexing Annotation English:   /biosyn /physiol permitted; DF: CYCL GMP
History Note English:   94; was GUANOSINE CYCLIC MONOPHOSPHATE 1980-93, was GUANOSINE CYCLIC-3',5'-MONOPHOSPHATE 1978-79, was GUANOSINE CYCLIC 3',5' MONOPHOSPHATE 1971-77 (Prov 1971); CYCLIC GMP was see GUANOSINE CYCLIC MONOPHOSPHATE 1975-93; GUANOSINE CYCLIC 2',3'-MONOPHOSPHATE was see GUANOSINE CYCLIC MONOPHOSPHATE 1980-93 
Allowable Qualifiers English:  
AD administration & dosage AE adverse effects
AG agonists AA analogs & derivatives
AN analysis AI antagonists & inhibitors
BI biosynthesis BL blood
CF cerebrospinal fluid CS chemical synthesis
CH chemistry CL classification
CT contraindications DF deficiency
DU diagnostic use EC economics
GE genetics HI history
IM immunology IP isolation & purification
ME metabolism PK pharmacokinetics
PD pharmacology PH physiology
PO poisoning RE radiation effects
SE secretion ST standards
SD supply & distribution TU therapeutic use
TO toxicity UR urine
Record Number:   31736 
Unique Identifier:   D006152 

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